Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge

Production of CyCMV/influenza vaccines

The CyCMV vector constructs used in this study were based on the published FL-CyCMV (strain 31908) bacterial artificial chromosome (BAC) and were generated by en passant homologous recombination^28,29. The codon optimized DNA sequences of the Influenza A…